The two-day event will be held in Lugano, in English. It is mainly aimed at doctors. However, patient and self-help representatives are welcome and can attend free of charge. On the first day, there will be a session for patient representatives in the morning (also in English). It is not yet known whether digital participation will also be possible.

Date:
September 21^st bis 22^nd 2023

Venue:
USI Università della Svizzera Italiana
Aula Magna,
Lugano, Switzerland

Programm:

September 21^st 2023

09:00 – 10:30 Patients’ session

• Pregnancy – Michael Heneghan
• Drug side effects – Maria Isabel Lucena and Raul Andrade
• New therapies – Michael Manns

Invited:

• SwissHePa
• UK PBC Foundation
• AMAF – TBC
• Deutsche Leberhilfe
• British Liver Trust – TBC
• Globalliver

11:00 – 11:15 Welcome Benedetta Terziroli Beretta-Piccoli and Andrea De
Gottardi
Welcome from Università della Svizzera Italiana – Giovanni
Pedrazzini

Basic science sessions

11:15 – 12:55 1. Genetics – Chairs: Gideon Hirschfield and Federica Sallusto
11:15 – 11:35 Genetics of PBC – Pietro Invernizzi
11:35 – 11:55 Genetics of PSC – Tom Karlsen
11:55 – 12:15 Genetics of AIH – Ynto de Boer
12:15 – 12:35 Inherited immune deficiencies and autoimmunity – Mike
Recher
12:35 – 12:55 Discussion

12:55 – 13:45 Lunch

13:45-16:40 2. Hot topics in autoimmune liver diseases – Chairs: Michael
Manns and Michael Trauner
13:45 – 14:05 Cellular therapies – Maria Serena Longhi
14:05 – 14:25 SARS-CoV-2 and liver autoimmunity – Gideon Hirschfield
14:25 – 14:45 Pregnancy in autoimmune liver diseases patients – Michael
Heneghan
14:45 – 15:05 Drug-induced AIH-like DILI – Maribel Lucena
15:05 – 15:25 Discussion

15:25 – 16:00 Coffee break

16:00 – 17:00 3. Oral presentations – Chairs: Michael Heneghan and
Giorgina Mieli-Vergani
16:00 – 16:15 Oral presentation 1
16:15 – 16:30 Oral presentation 2
16:30 – 16:45 Oral presentation 3
16:45 – 17:00 Oral presentation 4

17:00-18:20 4. Mechanisms of autoimmunity – Chairs: Diego Vergani and
Andreas Cerny
17:00 – 17:20 The Long and Latent Road to Autoimmunity – Eric Gershwin
17:20 – 17:40 T cells in autoimmunity – Federica Sallusto
17:40 – 18:00 Viruses and autoimmunity – Christian Münz
18:00 – 18:20 Discussion

18:20 – End of first day

September 22^th 2023

Clinical session

08:30 – 10:00 1. Diagonostic dilemmas – Chairs: Andrea De Gottardi and Andreas Kremer
08:30 – 08:45 Radiological clinical case presentation: the diagnosis of PSC
– Stefano Cappio and his fellow
08:45 – 09:05 Imaging in PSC and ASC – Annamaria Deganello
09:05 – 09:20 Serological case presentation: the diagnosis of AIH – Eric
Dayer and Benedetta Terziroli Beretta-Piccoli
09:20 – 09:40 Are autoantibodies still useful in the AI era? – Diego Vergani
09:40 – 10:00 Discussion

10:00 – 10:30 Coffee break

10:30 – 11:50 2. Treatment – Chairs: Andreas Kremer and Raul Andrade
10:30 – 10:50 Novel therapeutic targets for autoimmune cholestatic liver
diseases – Michael Trauner
10:50 – 11:10 Treatment of cholestatic pruritus – Andreas Kremer
11:10 – 11:30 Difficult to treat AIH patients – Ansgar Lohse
11:30 – 11:50 Discussion

11:50 – 12:50 Oral presentations – Chairs: Benedetta Terziroli Beretta-Piccoli
and Pietro Invernizzi
11:50 – 12:05 Oral presentation 1
12:05 – 12:20 Oral presentation 2
12:20 – 12:35 Oral presentation 3
12:35 – 12:50 Oral presentation 4

12:50-13:50 Lunch

13:50- 14:50 3. Pediatrics – Chairs: Giorgina Mieli-Vergani and Gideon
Hirschfield
13:50 – 14:05 Case presentation – Christiane Sokollik
14:05 – 14:25 Sclerosing cholangitis in pediatric IBD patients – Patrick van
Rheenen
14:25 – 14:45 Growing up with autoimmune liver disease: longterm
outcome of autoimmune liver disease – Marianne Samyn
14:45 – 15:05 Discussion

15:05 – 15:30 Coffee break

15:30 – 17:00 4. Checkpoint-inhibitors and the liver – Ansgar Lohse and
Maria Isabel Lucena
15:30 – 15:45 Clinical case presentation – Antonio Galante
15:45 – 16:05 Checkpoint-inhibitors-induced liver injury – Eleonora de
Martin
16:05 – 16:25 Liver histology of checkpoint-inhibitors-induced liver injury
– Yoh Zen
16:25 – 16:45 Can checkpoint inhibitors be used in patients with
autoimmune liver diseases? – Michael Manns
16:45 – 17:00 Discussion

17:00 – 17:20 Concluding remarques
Benedetta Terziroli Beretta-Piccoli
Andreas Kremer
Carina Bobzin
Robert Mitchell-Thain

17:20 End of the 4th Swiss AILD Meeting

Scientific committee:
Benedetta Terziroli Beretta-Piccoli – Chair
Andrea Cerny
Andrea De Gottardi
Diego Vergani
Giorgina Mieli-Vergani
Andreas Kremer

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